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Acetyl-CoA Substance formed as an intermediary product during cell metabolism in mammals. TKTL1 is able to form acetyl-CoA as a crucial building block for cell division.
Aerobic glycolysis Type of energy generation in cells in the presence of an adequate supply of oxygen. Aerobic glycolysis generates more energy carriers than anaerobic glycolysis.
ApoptosisA form of programmed cell death that is initiated and carried out by the cell itself.
Anaerobic glycolysis Type of energy generation in cells by fermentation of sugar to lactic acid without use of oxygen. Fewer energy carriers are generated than in aerobic glycolysis.
Cell cycle Describes the different phases in which cell division takes place.
DNaseXDNaseX is a gene that forms an enzyme of the same name. The enzyme cuts DNA into fragments in the final step of apoptosis. Without DNaseX or when it is inhibited, increased degeneration of cells occurs.
EDIM technology Short for Epitope Detection in Monocytes. This technology is used to detect specific antigens in human immune cells. TKTL1 is one of the biomarkers used for this purpose.
Homodimer Protein complex consisting of two identical basic units.
Heterodimer – protein complex consisting of two different basic units
HeterodimerProtein complex consisting of two different basic units
HypoxiaMedical term for oxygen deficiency
Krebs-ScanKrebs-Scan is an optional service which includes the PanTum Detect® blood test and is offered by HanseMerkur Krankenversicherung.
PanTum Detect®PanTum Detect® is a blood test developed by Zyagnum AG that is used to identify people who benefit from imaging diagnostics (PET CT, MRI) for the early detection of cancer. TKTL1 is one of the two biomarkers used in this test.
Ribose-5-phosphate Basic building block for the formation of new DNA. Ribose-5-phosphate gives cells the impulse for cell division.
Warburg effect – describes an altered type of glucose metabolism, particularly in cancer cells, which leads to the secretion of lactate. Healthy cells use this metabolic pathway only in the absence of oxygen.